Browsing by Author "Tutar, Lutfi"
Now showing items 1-9 of 9
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Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
Gumus, Mehmet; Ozgur, Aykut; Tutar, Lutfi; Disli, Ali; Koca, Irfan; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2016)Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target ... -
Heat Shock Proteins; An Overview
Tutar, Lutfi; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2010)Heat shock proteins (Hsps) protect protein substrates against conformational damage to promote the function of the proteins, prevent aggregation and prevent formation of toxic inclusion bodies. Protein aggregates and fibrils ... -
Heat, pH Induced Aggregation and Surface Hydrophobicity of S. cerevesiae Ssa1 Protein
Tutar, Yusuf; Arslan, Derya; Tutar, Lutfi (SPRINGER, 2010)Heat shock protein 70 is a conserved protein among organisms. Hsp70 helps substrate proteins to fold correctly. Unfolded substrate proteins increase the probability of the aggregate formation. High level recombinant protein ... -
Isolation and Identification of Free-Living Amoebae from Tap Water in Sivas, Turkey
Coskun, Kubra Acikalin; Ozcelik, Semra; Tutar, Lutfi; Elaldi, Nazif; Tutar, Yusuf (HINDAWI PUBLISHING CORPORATION, 2013)The present work focuses on a local survey of free-living amoebae (FLA) that cause opportunistic and nonopportunistic infections in humans. Determining the prevalence of FLA in water sources can shine a light on the need ... -
MicroRNAs and Cancer; an Overview
Tutar, Lutfi; Tutar, Esen; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2014)MiRNAs are a family of small, endogenous, and evolutionarily conserved non-coding ribonucleic acids that have been involved in the regulation of several essential, cellular, and functional processes. MicroRNAs are known ... -
Regulation of oncogenic genes by MicroRNAs and pseudogenes in human lung cancer
Tutar, Yusuf; Ozgur, Aykut; Tutar, Esen; Tutar, Lutfi; Pulliero, Alessandra; Izzotti, Alberto (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Lung cancer is one of the most common mortal cancer types both for men and women. Several different biomarkers have been analyzed to reveal lung cancer prognosis pathways for developing efficient therapeutics and diagnostic ... -
Therapeutic Targeting of microRNAs in Cancer: Future Perspectives
Tutar, Lutfi; Tutar, Esen; Ozgur, Aykut; Tutar, Yusuf (WILEY-BLACKWELL, 2015)The discovery of microRNAs (miRNAs) and their link with cancer has opened a new era in cancer therapeutics. Approximately, 18-24 nucleotides long, miRNAs can up-regulate or down-regulate gene expression in many cancer types ... -
Tumor Targeting of Polymeric Nanoparticles Conjugated with Peptides, Saccharides, and Small Molecules for Anticancer Drugs
Bayram, Banu; Ozgur, Aykut; Tutar, Lutfi; Tutar, Yusuf (BENTHAM SCIENCE PUBL LTD, 2017)Targeting drugs or pharmaceutical compounds to tumor site increases cancer treatment efficiency and therapeutic outcome. Nanoparticles are unique delivery systems for site-targeting within an organism. Many novel technologies ... -
Ydj1 but not Sis1 stabilizes Hsp70 protein under prolonged stress in vitro
Tutar, Lutfi; Tutar, Yusuf (JOHN WILEY & SONS INC, 2008)Yeast cytosol has two important co-chaperons; Ydj1 and Sis1. Genetic experiments showed that Ydj1 is not I essential for viability; however, cells lacking it grow very poorly at 30 degrees C or unable to grow at extreme ...